Investigating the Effect of Dynamics Employment and Institutional Factors with a Focus on Economic Freedom and Ease Doing of Business on GDP per Capita in Iran

Purpose: Since employment and growth is an important and key issue in the economy, having an efficient environment is very important for proper growth. Therefore, in order to improve the current situation and achieve proper development, it is necessary to study the effect of Dynamics Employment and institutional factors in order to identify the effective channels to improve the current situation, effective factors and appropriate growth. Methodology: Therefore, the main purpose of this study is to investigate the effect of Dynamics Employment on GDP per capita in Iran during the period 2004-2021 using the generalized time series torque method. Findings: The results show that Dynamics Employment have a significant effect on Iran's per capita GDP; Thus, the dependency rate of the elderly, the dependency rate of children and the negative impact and the participation rate, labor productivity rate, employment rate have a positive impact on GDP per capita. The results also show that institutional factors have a significant impact on GDP per capita growth and improving the indicators of economic freedom and ease of doing business, which are the most important institutional factors, accelerate growth and development. Originality/Value: This paper investigated the effect of Dynamics Employment and institutional factors with a focus on economic freedom and Ease Doing of Business on GDP per capita in Iran

Investigating the Impact of Digital Marketing and Its Effectiveness on Career Growth through Export Performance (Case Study of Top Commercial Companies in East Azerbaijan Province in Iran)

The issue of growth is one of the fundamental issues in economics, which is very important both from a micro and macro perspective. It is no secret that in order to achieve sustainable growth, exports are one of the most fundamental variables, which is the main channel of monetization. For optimal export, you should have a good market share. Digital marketing is one of the most widely used tools to expand the market, so the present study has studied the effectiveness of digital marketing on job growth through export performance. The statistical population of the present study consists of 500 commercial companies in East Azerbaijan province, of which 271 companies have been selected as a statistical sample according to Morgan table and using Cochran's formula. Also, the data collection tool in this study is a questionnaire with Likert scale. Structural equation modeling and SPSS software version 25 and Smart PLS version 3 were used to analyze the data. The results indicate that digital marketing and export performance have a positive effect on job growth and micro and macro development.

A Novel Hybrid Algorithm for Optimized Solutions in Ocean Renewable Energy Industry: Enhancing Power Take-Off Parameters and Site Selection Procedure of Wave Energy Converters

Ocean renewable energy, particularly wave energy, has emerged as a pivotal component for diversifying the global energy portfolio, reducing dependence on fossil fuels, and mitigating climate change impacts. This study delves into the optimization of power take-off (PTO) parameters and the site selection process for an offshore oscillating surge wave energy converter (OSWEC). However, the intrinsic dynamics of these interactions, coupled with the multi-modal nature of the optimization landscape, make this a daunting challenge. Addressing this, we introduce the novel Hill Climb - Explorative Gray Wolf Optimizer (HC-EGWO). This new methodology blends a local search method with a global optimizer, incorporating dynamic control over exploration and exploitation rates. This balance paves the way for an enhanced exploration of the solution space, ensuring the identification of superior-quality solutions. Further anchoring our approach, a feasibility landscape analysis based on linear water wave theory assumptions and the flap's maximum angular motion is conducted. This ensures the optimized OSWEC consistently operates within safety and efficiency parameters. Our findings hold significant promise for the development of more streamlined OSWEC power take-off systems. They provide insights for selecting the prime offshore site, optimizing power output, and bolstering the overall adoption of ocean renewable energy sources. Impressively, by employing the HC-EGWO method, we achieved an upswing of up to 3.31% in power output compared to other methods. This substantial increment underscores the efficacy of our proposed optimization approach. Conclusively, the outcomes offer invaluable knowledge for deploying OSWECs in the South Caspian Sea, where unique environmental conditions intersect with considerable energy potential.Comment: 35 pages, 22 Figures, 7 Table

Mutation detection in exons 3, 10, 12 of BRCA1 gene in 30 patients affected with familial breast cancer

Breast Cancer is one of the most common causes of death due to Cancer in women. More than half of hereditary breast/ovarian Cancer families could be attributed to mutation in breast Cancer susceptibility gene BRCA1. This study was performed on blood samples of 30 women who affected with familial breast Cancer. Non-radioactive PCR-SSCP technique was utilized mutation screening in exons 3, 10, 12 of BRCA1 gene. Two shifts in exon 3 and also two in exon 12 was detected, but no shift in exon 10 was found. Due to low number of

The study of potassium ferrate application efficiency for advanced treatment of sewage

زمینه و هدف: طیف وسیعی از منعقد کننده‌ها، اکسیدان‌ها و گندزداها در تصفیه آب و فاضلاب استفاده می‌شوند. یون فرات به عنوان یک اکسیدان قوی بالاترین پتانسیل اکسیداسیون-احیاء را بین همه اکسیدان‌ها و گندزداها در تصفیه آب و فاضلاب داراست. یون فرات (شش ظرفیتی) در آب به یون هیدروکسید فریک احیا می‌شود و می‌تواند در یک فرآیند چند منظوره به عنوان منعقد کننده، اکسیدان و گندزدا مورد استفاده قرار گیرد. هدف از این مطالعه بررسی فرآیند تصفیه پیشرفته پساب فاضلاب شهری با استفاده از فرات پتاسیم بود. روش بررسی: در این مطالعه نیمه تجربی تصفیه پیشرفته فاضلاب شهری توسط فرات‌پتاسیم در مقیاس آزمایشگاهی روی پساب فاضلاب گندزدایی نشده با تعیین اثر متغیرهای pH و غلظت بر میزان حذف کدورت، ترکیبات ارگانی آب (COD) و فسفر مورد بررسی قرار گرفت. به منظور تعیین کارایی گندزدایی فرات پتاسیم نیز اثر سه متغیر زمان تماس، غلظت فرات و pH روی فرآیند گندزدایی با استفاده از شاخص (MPN (Most Probable Number مشخص شد. یافته‌ها: بهترین راندمان حذف ترکیبات ارگانی آب و کدورت با استفاده از فرات‌پتاسیم در شرایط بهینه (5=pH و غلظت mg/L10) به ترتیب 65 و 90 بود. pH و غلظت بهینه فرات ‌پتاسیم در حذف فسفر نیز 5=pH و غلظت mg/L 12 بود که موجب حذف 72 درصدی فسفر شد. بهترین شرایط کاربرد فرات پتاسیم به عنوان گندزدا در غلظت mg/L 4 و زمان تماس های 25 دقیقه و 6=pH بود. نتیجه گیری: فرات ‌پتاسیم به عنوان یک ماده شیمیایی مؤثر اکسید کننده، گندزدا و منعقد کننده می ‌تواند در تصفیه انواع پساب های شهری و صنعتی مورد استفاده قرار گیرد و با این کار دسترسی به چند هدف در یک فرآیند را میسر گرداند

Effects of systemic administration of HESA-A on the expression of cyclin D1 and EGFR and E-cadherin in the induced tongue dysplasia in rats

Background. HESA-A has herbal and marine bases, containing minerals and rare elements such as Zr, Cr, Ga, Mn, Mg, Ca, Sr, Cu, Ti, etc. Its mechanism of action includes antioxidant, antiinflammatory and adjustment of the immune system. The aim of this study was to evaluate the effects of HESA-A systemic drug on expression of cyclin D1, EGFR and E-cadherin in induced tongue dysplasia in rats. Methods. In this experimental study, the effects of the systemic drug HESA-A on the expression of cyclin D1, EGFR, and E-cadherin molecular markers were examined in induced tongue dysplasia in rats. Results. The incidence rate of cyclin D1 in groups receiving HESA-A was lower than the group that did not receive the drug (77.78% in the 0‒5% range versus 77.78% in the 5‒50% range). In the case of expression of E-cadherin in group D, which did not receive HESA-A, a decrease was observed in the expression of this cell adhesion marker as compared to the other two groups. The incidence of E-cadherin was dependent on HESA-A dose, while with 500 mg/kg it was higher than other groups (>75% in 55.55% versus >75% in 11.11%). Concerning the incidence of EGFR in all the three groups most cases were grade 0. Conclusion. The results of the present research indicated that considering changes in the expression of cyclin D1 and E-cadherin markers in groups treated with HESA-A, HESA-A® has preventive effects on development of cancer in dysplastic lesions through regulation of expression of these molecules

A Comparison Study of the Tehran Norms to the Reference Norms on Children Performance of the Bayley III

Objectives The Bayley Scales of Infant and Toddler Development (Bayley III) assess cognitive, language, and motor development of children aged 1–42 months, and have been widely used globally. It is unclear whether or not the reference norms of the Bayley III are acceptable for use in other populations or lead to over or under-estimating development. The purpose of this study was to estimate the distribution of the Bayley scores by age in Persian speaking children and to compare the norms between Persian and reference norms. Materials & Methods We constructed Bayley III norms for cognitive, language, and motor scales using 1,674 typically developing children by consecutive sampling from health care centers. First cut-off point was determined, and then the scaled scores, based on Persian speaking and reference norms, were compared. The proportions of children with low scores (scoring less than -1SD and -2 SD) based on the two norms were compared, to identify over or under-referral for developmental delay resulting from reference norms. Results Scaled scores based on Persian norms varied across values based on reference norms on all subtests. The mean differences were significant across all five sub-tests (p < .05), with large effect sizes for receptive and expressive communication, fine and gross motor sub-tests of .20, .23, .14, and .25 respectively, and with small effect size for cognition sub-test of .02. Large effect sizes for all age groups were found for cognition, expressive communication, and fine motor sub-tests. For the receptive communication sub-test, effect sizes were generally large, with the exception of four age groups. For the gross motor sub-test, effect sizes were generally large, with the exception of six age groups. More children scored below 1 and 2 SD using the Persian norms and resulted in under-referral regarding cognitive, receptive and expressive communication, fine and gross motor skills. Conclusion The Persian norms differ from the reference norms for all sub-tests and these differences are clinically significant. The use of the reference norms leads to fewer referrals in all sub-scales and leads to fewer diagnoses of children with developmental delay. Population specific norms are required to identify children with low scores for referral and intervention

Repositioning of the global epicentre of non-optimal cholesterol

High blood cholesterol is typically considered a feature of wealthy western countries(1,2). However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world(3) and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health(4,5). However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol-which is a marker of cardiovascular riskchanged from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million-4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world.Peer reviewe